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博士生导师

张猛

教授、研究员
博导
zhangmeng@sdu.edu.cn
个人简介 学术论文 学会任职 其他介绍
张猛,教授、博士生导师,长江学者青年专家,山东省杰出青年基金获得者,山东省优秀青年基金获得者,山东省泰山学者青年专家。兼任中华心血管病学会信息化学组委员、山东省免疫学会青年委员会副主任委员,山东省抗癌协会青年理事会常务理事、山东省肿瘤心脏病学会常委、山东省心血管病学会基础学组委员等职务。主要研究方向心血管病发病的免疫调控机制及干预策略研究。近年来,作为第一及通讯作者在Nat Immunol、Sci Trans Med、Signal Transduct Target Ther、Cell Mol Immunol、J Exp Med、Adv SciAutophagyCell Death Differ、Arterioscler Thromb Vasc Biol等权威杂志发表 SCI 论文10余篇。作为项目负责人承担国家自然科学基金4项、省部级课题7项,累计经费700余万元;曾获得教育部自然科学一等奖、教育部博士学术新人奖,山东省优秀博士论文奖,国际F1000 Prime学术论文奖等多项奖励。




学术论文:

(1) Guo C, et.al. NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. Adv Sci. 2023 Sep 5:e2303283. (通讯作者)

(2) Qiao L, et.al. LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles. Autophagy. 2023 Jul 21:1-16. (通讯作者)

(3) Zhang J, et.al. E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978. (通讯作者)

(4) Li Q, et.al. METTL3 Dependent N6-Methyladenosine Modification on Braf mRNA Promotes Macrophage Inflammatory Response and Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2023 May;43(5):755-773. (通讯作者)

(5) Yu L, et.al. Heterogeneity of macrophages in atherosclerosis revealed by single-cell RNA sequencing. FASEB J. 2023 Mar;37(3):e22810. (通讯作者)

(6) Yu L, et.al. An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic aneurysm formation. Signal Transduct Target Ther. 2022, 7(125). (通讯作者)

(7) Qiao L, et.al. Vascular macrophages sense octanal and drive athero-inflammation. Cell Mol Immunol. 2022 Oct;19(10):1077-1078. (通讯作者)

(8) Zhang J, et.al. The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway. Cell Death Differ. 2022 Mar;29(3):556-567. (通讯作者)

(9) Zhang M, et.al. An animal model of EPO-induced abdominal aortic aneurysm in WT and Apoe-/-mice. STAR Protocols. 2022 Dec 15;4(1):101929. (通讯作者)

(10) Zhang M, et.al. Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration. Sci Transl Med. 2021 Jul 21, 13(603), eaaz4959. (通讯作者)

(11) Cheng J, et.al. TRIM31 Deficiency Is Associated with Impaired Glucose Metabolism and Disrupted Gut Microbiota in Mice. Front Physiol. 2018; 9:24. (通讯作者)

(12) Liu B, Zhang M, et.al. The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol. 2017, 18(2):214-224. (第一作者)

(13) Zhang M, et.al. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med. 2012, 209(10):1703-11. (第一作者)

(14) Zhao W, Zhang M, et.al. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1, J Immunol. 2012, 188(11):5311-8. (第一作者)Z


学会任职

中华心血管病学会信息化学组委员

山东省免疫学会青年委员会副主任委员

山东省心血管病学会基础学组委员

山东省抗癌协会青年理事会常务理事

山东省肿瘤心脏病学会常务委员




1,国家自然基金面上项目,82270487,2023.01-2026.12,52万元,主持


2,国家自然基金面上项目,81970373,2020.01-2023.12,55万元,主持


3,国家自然基金面上项目,31770977,2018.01-2021.12,60万元,主持


4,国家自然基金青年项目,31400771,2015.01-2017.12,26万元,主持


5,中央高校优秀青年团队项目,2023.01-2025.12200万元,主持


6,山东省杰出青年基金项目,ZR2023JQ0302024.01-2026.12100万元,主持


7,山东省重点研发计划子课题,2021ZDSYS05-2,2022.01- 2024.12,50万元,主持


8, 山东省青年泰山学者建设项目,qnts201812131,2019.01-2023.12,150万元,主持


9,山东省优秀青年基金项目ZR2020YQ53,2021.01-2023.12, 40万元,主持


10,山东省自然基金青年项目,ZR2014CQ004,2015.01-2017.12,12万,主持