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博士生导师

钟明

主任医师
博导
个人简介 学术论文 其他介绍

钟明,山东大学齐鲁医院心内科教授,博士生导师,美国心脏病学院专家会员(FACC),山东省医药卫生中青年重点科技人才,2007.5-2008.5年作为访问学者赴加拿大多伦多大学St. Michael医院学习。长期以来一直在临床第一线工作,擅长冠心病、心力衰竭和顽固性高血压等疾病的诊治,对多种心脏病的超声诊断有丰富的经验。

作为项目负责人承担国家自然基金、973、山东省科技攻关和自然基金等课题10余项。作为第一承担者获山东省科技进步二等奖1项;以第一作者/通讯作者发表SCI收录文章44篇;参编著作2部

担任中华医学会心血管病学分会高血压学组委员,山东省医师协会心内科医师分会副主任委员,山东省医学会心血管病学分会心衰学组副组长,山东省医学会心脏康复分会副主任委员

1.国家自然科学基金面上项目,82070392,脂肪细胞源exosomes调控PTPN2可变剪接介导的T细胞极化在糖尿病性心肌病中的作用和机制研究,2021/01-2024/12,55万元,在研,主持

2.山东省重点研发计划,2019GSF108041,Pim-1/PPARγ信号通路诱导肌少症形成中的作用及其机制研究,2015/01-2020/12,15万元,在研,主持

3.国家自然科学基金面上项目,81470560,脂肪细胞来源Microparticles介导新生血管生成在2型糖尿病易损斑块形成中的作用,2015/01-2018/12,73万元,在研,主持

4.山东省重点研发计划,2015GSF118062,Microvesicles介导血小板活化在非瓣膜性房颤脑卒中的研究,2015/01-2017/12,10万元,在研,主持

5.973计划项目子课题,2013CB530700,血管衰老及相关疾病的生物学基础,2013/01-2016/12,160万元,在研,学术骨干

6.国家自然科学基金面上项目,81270287,PGF2α-FP受体信号通路在调控糖尿病性心肌病心肌间质纤维化中的作用,2013/01-2016/12,78万元,结题,主持

7.973计划项目子课题,2012CB722406,代谢性因素在心力衰竭发病中的作用机制研究,2012/01-2015/12,120万元,结题,学术骨干

8.教育部留学基金,糖尿病易损斑块发生的分子机制研究,2009ZRB019CQ,2011-2013,3万元,已结题,主持

9.山东省自然科学基金,糖尿病动脉粥样硬化发生机制和干预的研究,ZR2009CM025,2010/01-2013/12,5万元,已结题,主持

10.国家自然科学基金面上项目,30971215,STAMP2/Akt信号传导通路在2型糖尿病ApoE-/-LDLr-/-小鼠易损斑块形成中的作用,2010/01-2012/12,33万元,已结题,主持

11.国家自然科学基金面上项目,30570748,糖/TSP-1/TGFβ1/Smads信号传导通路在糖尿病心肌病发病中的作用,2006/01-2008/12,26万元,已结题,主持

12.山东省科技攻关项目,2006GG2202020,AngII/TSP-1/TGFβ1/Smads信号传导途径在糖尿病血管病变中作用,2006-2009,8万元,已结题,主持

13.山东省优秀中青年科学家奖励基金,04BS03009,糖尿病性心肌病发病机制和干预的初步研究,2005-2008,6万元,已结题,主持

14.山东省医药卫生行业“1020”计划重点培养的青年科学家专项,2005-2008,10万元,已结题


代表性研究成果和学术奖励情况(每项均按时间倒序排序)

一、期刊论文(仅不列此项时可删除该标题)

请按如下顺序列出:

第一作者论文(仅不列此项时可删除该标题)


15.Zhong M#, Tan HW, Gong HP, Wang SF, Zhang Y, Zhang W*, Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis, Clin Endocrinol (Oxf), 2008, 69(6):878-884.

16.Tang M#, Zhong M#, Shang Y, Lin H, Deng J, Jiang H, Lu H, Zhang Y, Zhang W*, Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway, Cell Mol Life Sci, 2008, 65(18):2924-2932.

通讯作者论文(勿与第一作者论文重复)(仅不列此项时可删除该标题,序号按实际情况编排)

17.Zhou HM#, Ti Y#, Wang H, Shang YY, Liu YP, Ni XN, Wang D, Wang ZH, Zhang W, Zhong M*.Cell death-inducing DFFA-like effector C/CIDEC gene silencing alleviates diabetic cardiomyopathy via upregulating AMPKa phosphorylation.

18.Du J#, Li Y, Sun Q, Wang Z, Wang F, Chen F, Wang H, Liu Y, Zhou H, Shang G, Chen X, Ding S, Li C, Wu D, Zhang W, Zhong M*.Urinary exosomal CD26 is associated with recovery from acute kidney injury in intensive care units: a prospective cohort study.Clin Chem Lab Med. 2021 Apr 21. doi: 10.1515/cclm-2021-0040. Online ahead of print.

19.Zheng GS#, Tan YM, Shang YY, Liu YP, Hu BA, Wang D, Han L, Wang ZH, Zhang W, Ti Y*, Zhong M*.CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.J Diabetes Investig. 2021 Mar 2. doi: 10.1111/jdi.13534. Online ahead of print.

20.Zhang X#, Zhang L, Tan YM, Liu YP, Li JJ, Deng QM, Yan SB, Zhang W, Han L*, Zhong M*.Hepcidin gene silencing ameliorated inflammation and insulin resistance in adipose tissue of db/db mice via inhibiting METs formation.Mol Immunol. 2021 May;133:110-121.

21.Chen YQ#, Zhou HM#, Chen FF, Liu YP, Han L, Song M, Wang ZH, Zhang W, Shang YY, Zhong M*. Testosterone ameliorates vascular aging via the Gas6/Axl signaling pathway, Aging (Albany NY), 2020,12(16):16111-16125.

22.Wang H#, Song NP, Li JP, Wang ZH, Ti Y, Li YH, Zhang W, Zhong M*.The microvesicle/CD36 complex triggers a prothrombotic phenotype in patients with non-valvular atrial fibrillation.J Cell Mol Med. 2020 Jul;24(13):7331-7340.

23.Wei C#, Liu Y, Li Y, Zhang Y, Zhong M*, Meng X*, Evaluation of the nutritional status in patients with COVID-19, J Clin Biochem Nutr, 2020,67(2):116-121.

24.Wang H#, Song NP, Li JP, Wang ZH, Ti Y, Li YH, Zhang W, Zhong M*, The microvesicle/CD36 complex triggers a prothrombotic phenotype in patients with non-valvular atrial fibrillation, J Cell Mol Med, 2020, 24(13):7331-7340.

25.Wei CY#, Wang YM#, Han L, Chen FF, Li YH, Tang MX, Zhang W, Wang ZH*, Zhong M*, Nitrate Esters Alleviated Coronary Atherosclerosis Through Inhibition of NF-κB-Regulated Macrophage Polarization Shift in Epicardial Adipose Tissue, J Cardiovasc Pharmacol, 2020,75(5):475-482.

26.Ni XN#, Yan SB, Zhang K, Sai WW, Zhang QY, Ti Y, Wang ZH, Zhang W, Zheng CY*, Zhong M*, Serum complement C1q level is associated with acute coronary syndrome, Mol Immunol, 2020,120:130-135.

27.Shang GK#, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M*, Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles, J Cachexia Sarcopenia Muscle, 2020,11(4):1104-1120.

28.Wang H#, Zhong L, Mi S, Song N, Zhang W, Zhong M*, Tanshinone IIA prevents platelet activation and down-regulates CD36 and MKK4/JNK2 signaling pathway, BMC Cardiovasc Disord, 2020,20(1):81.

29.Yan SB#, Wang XY, Shang GK, Wang ZH, Deng QM, Song JW, Sai WW, Song M, Zhong M*, Zhang W*, Impact of Perioperative Levosimendan Administration on Risk of Bleeding After Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials, Am J Cardiovasc Drugs, 2020,20(2):149-160.

30.Li Y#, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M*, PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy, J Cell Mol Med, 2019,23(6):4179-4195.

31.Chen FF#, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J*, Zhong M*, Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice, Exp Gerontol, 2019,119:128-137.

32.Yang LW#, Song M, Li YL, Liu YP, Liu C, Han L, Wang ZH, Zhang W, Xing YQ*, Zhong M*, L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway, Biogerontology, 2019,20(2):203-211.

33.Wang F#, Chen FF#, Shang YY, Li Y, Wang ZH, Han L, Li YH, Zhang L, Ti Y, Zhang W, Zhong M*, Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE-/- mice, Int J Cardiol, 2018,265:181-187.

34.Li Y#, Zhou H, Wang F, Han L, Liu M, Li Y, Wang Z, Tang M, Zhang W, Zhong M*, Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice, Cell Physiol Biochem, 2018,46(1):118-132.

35.Shang G#, Yang X, Song D, Ti Y, Shang Y, Wang Z, Tang M, Zhang Y, Zhang W, Zhong M*, Effects of Levosimendan on Patients with Heart Failure Complicating Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials, Am J Cardiovasc Drugs, 2017,17(6):453-463.

36.Liu MH#, Li Y, Han L, Zhang YY, Wang D, Wang ZH, Zhou HM, Song M, Li YH, Tang MX, Zhang W, Zhong M*, Adipose-derived stem cells were impaired in restricting CD4+T cell proliferation and polarization in type 2 diabetic ApoE-/- mouse, Mol Immunol, 2017, 87:152-160.

37.Chen YQ#, Zhao J, Jin CW, Li YH, Tang MX, Wang ZH, Zhang W, Zhang Y, Li L, Zhong M*, Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway, Age (Dordr), 2016, 38(3):60.

38.Li Y#, Han L, Ding WY, Ti Y, Li YH, Tang MX, Wang ZH, Zhang Y, Zhang W, Zhong M*, Prostaglandin F2αreceptor silencing attenuates vascular remodeling in rats with type 2 diabetes, Exp Mol Pathol, 2015, 99(3):517-523.

39.Zhao J#, Yan HM, Li Y, Wang J, Han L, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong M*, Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia, J Zhejiang Univ Sci B, 2015, 16(5):380-387.

40.Zhang XJ#, Wei CY, Li WB, Zhang LL, Zhou Y, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong M*, Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis, Thromb Res, 2015, 136(1):45-51.

41.Sun H#, Zhao Y, Bi X, Li S, Su G, Miao Y, Ma X, Zhang Y, Zhang W, Zhong M*, Valsartan blocks thrombospondin/transforming growth factor/Smads to inhibit aortic remodeling in diabetic rats, Diagn Pathol, 2015, 10(1):18-26.

42.Jin CW#, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M*, Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway, Cell Physiol Biochem, 2015, 35(3):1151-1166.

43.Shang YY#, Fang NN, Wang F, Wang H, Wang ZH, Tang MX, Peng J, Zhang Y, Zhang W, Zhong M*, MicroRNA-21, induced by high glucose, modulates macrophage apoptosis via programmed cell death 4, Mol Med Rep, 2015, 12(1):463-469.

44.Su F#, Zhao L, Zhang S*, Wang J, Chen N, Gong Q, Tang J, Wang H, Yao J, Wang Q, Zhong M*, Yan J, Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig hearts, Lab Invest, 2015, 95(8):860-871.

45.Li Y#, Xiao Q, Zeng W, Guo H, Jiang K, Zhong M*, Zhong J, Red Blood Cell Distribution Width is Independently Correlated With Diurnal QTc Variation in Patients With Coronary Heart Disease.Medicine (Baltimore), 2015, 94(23):e822.

46.Wang J#, Han L, Wang ZH, Ding WY, Shang YY, Tang MX, Li WB, Zhang Y, Zhang W*, Zhong M*, Overexpression of STAMP2 suppresses atherosclerosis and stabilizes plaques in diabetic mice, J Cell Mol Med, 2014, 18(4):735-48.

47.Han L#, Fu KL, Zhao J, Wang ZH, Tang MX, Wang J, Wang H, Zhang Y, Zhang W, Zhong M*, Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults, Diabetol Metab Syndr, 2014, 6(1):143-149.

48.Ding WY#, Liu L, Wang ZH, Tang MX, Ti Y, Han L, Zhang L, Zhang Y, Zhong M*, Zhang W*, FP-receptor gene silencing ameliorates myocardial fibrosis and protects from diabetic cardiomyopathy, J Mol Med (Berl), 2014, 92(6):629-640.

49.Wang J#, Han L, Wang ZH, Ding WY, Shang YY, Tang MX, Li WB, Zhang Y, Zhang W, Zhong M*, Overexpression of STAMP2 suppresses atherosclerosis and stabilizes plaques in diabetic mice, J Cell Mol Med, 2014, 18(4):735-748.

50.Ding WY#, Li WB, Ti Y, Bi XP, Sun H, Wang ZH, Zhang Y, Zhang W, Zhong M*, Protection from renal fibrosis, putative role of TRIB3 gene silencing, Exp Mol Pathol, 2014, 96(1):80-84.

51.Zheng T#, Zhao J, Wang Y, Liu W, Wang Z, Shang Y, Zhang W, Zhang Y, Zhong M*, The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: a meta-analysis, Clin Biochem, 2014, 47(6):369-377.

52.Han L#, Tang MX, Ti Y, Wang ZH, Wang J, Ding WY, Wang H, Zhang Y, Zhang W, Zhong M*, Overexpressing STAMP2 improves insulin resistance in diabetic ApoE-/-/LDLR-/- mice via macrophage polarization shift in adipose tissues, PLoS One, 2013, 8(11):e78903.

53.Ding WY#, Ti Y#, Wang J, Wang ZH, Xie GL, Shang YY, Tang MX, Zhang Y, Zhang W #, Zhong M*, Prostaglandin F2αfacilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor/protein kinase C/Rho kinase pathway independent of transforming growth factorβ1, Int J Biochem Cell Biol, 2012, 44(6):1031-1039.

54.Liu WN#, Fu KL, Gao HY, Shang YY, Wang ZH, Jiang GH, Zhang Y, Zhang W, Zhong M*,β1 adrenergic receptor polymorphisms and heart failure: a meta-analysis on susceptibility, response toβ-blocker therapy and prognosis, PLoS One, 2012, 7(7):e37659.

55.Tang M#, Zhou F, Zhang W, Guo Z, Shang Y, Lu H, Lu R, Zhang Y, Chen Y, Zhong M*, The role of thrombospondin-1-mediated TGF-β1 on collagen type III synthesis induced by high glucose, Mol Cell Biochem, 2011, 346(1-2):49-56.

56.Yan HM#, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M*, The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia, Expert Opin Pharmacother, 2011, 12(10):1463-1471.

57.Ti Y#, Xie GL#, Wang ZH, Bi XL, Ding WY, Wang J, Jiang GH, Bu PL, Zhang Y, Zhong M*, Zhang W#, TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model, Diabetes, 2011, 60(11):2963-2974.

58.Li SH#, Tan HW, Wang ZH, Zhang Y, Zhong M*, Zhang W*, Evaluation of left ventricular synchronicity in hypertensive patients with overweight or obesity. Obesity (Silver Spring), 2010, 18(8):1545-51.

59.Wang ZH#, Zhang W, Gong HP, Guo ZX, Zhao J, Shang YY, Feng JB, Zhang Y, Zhong M*, Expression of STAMP2 in monocytes associates with cardiovascular alterations, Eur J Clin Invest, 2010, 40(6):490-496.

60.Gong HP#, Wang ZH#, Jiang H, Fang NN, Li JS, Shang YY, Zhang Y, Zhong M*, Zhang W*, TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis, Diabetes Care, 2009, 32(7):1311-1313.

61.Gong HP#, Zhang W, Li L, Tan HW, Ma ZY, Zhong XZ, Wang ZH, Song T, Zhang Y, Zhong M*, Possible beneficial effect of olmesartan medoxomil on left atrial function in patients with hypertension : noninvasive assessment by acoustic quantification, Clin Drug Investig, 2008, 28(4):241-249.

62.Tan HW#, Zheng GL, Li L, Wang ZH, Gong HP, Zhang Y, Zhong M*, ZhangW*, Impaired left ventricular synchronicity in hypertensive patients with ventricular hypertrophy, J Hypertens, 2008,26 (3): 553-9.

63.Tan HW#, Li L, Wang ZH, Xing SS, Bi XP, Zhong M*, Zhang W*, Impaired left ventricular systolic synchronicity in hypertensive patients with ventricular arrhythmias, Hypertens Res, 2007, 30(9):759-66.

既非第一作者又非通讯作者论文(仅不列此项时可删除该标题,序号按实际情况编排)

64.Wei C#, Liu Y, Liu Y, Zhang K, Su D, Zhong M, Meng X*, Clinical characteristics and manifestations in older patients with COVID-19, BMC Geriatr, 2020,20(1):395.

65.Chen FF#, Zhong M, Liu Y, Zhang Y, Zhang K, Su DZ, Meng X*, Zhang Y*, The characteristics and outcomes of 681 severe cases with COVID-19 in China, J Crit Care, 2020,60:32-37.

66.Meng X#, Liu Y, Wei C, Zhang K, Zhang Y, Zhong M, Zhang C*, Zhang Y*, Angiotensin converting enzyme inhibitors and angiotensin receptor blockers improved the outcome of patients with severe COVID-19 and hypertension, Sci China Life Sci, 2020,1–4.

67.Cao Y#, Zhong M, Zhang Y, Zheng Z, Liu Y, Ni X, Han L, Song M, Zhang W*, Wang Z*, Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome, Diabetes Metab Syndr Obes, 2020,13:81-88.

68.Qin RR#, Zhu H#, Wang F, Song M, Lin PL, Xing YQ, Zhang W, Zhong M, Wang ZH*, Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation, Aging (Albany NY), 2019,11(16):6358-6370.

69.Cao Y#, Sun XY, Zhong M, Li L, Zhang M, Lin MJ, Zhang YK, Jiang GH, Zhang W*, Shang YY*, Evaluation of hemodynamics in patients with hypertrophic cardiomyopathy by vector flow mapping: Comparison with healthy subjects, Exp Ther Med, 2019,17(6):4379-4388.

70.Lin LY#, Yang LW, Shang YY, Li YH, Zhong M, Zhang W, Zhu H*, Role of the CHADS2 Score in the Evaluation of Carotid Atherosclerosis in Patients with Atrial Fibrillation Undergoing Carotid Artery Ultrasonography, Biomed Res Int, 2018, 2018:4074286.

71.Song M#, Han L, Chen FF, Wang D, Wang F, Zhang L, Wang ZH, Zhong M, Tang MX*, Zhang W*, Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways, Cell Physiol Biochem, 2018,48(4):1416-1432.

72.Song M#, Chen FF, Li YH, Zhang L, Wang F, Qin RR, Wang ZH, Zhong M, Tang MX, Zhang W, Han L*, Trimetazidine restores the positive adaptation to exercise training by mitigating statin-induced skeletal muscle injury, J Cachexia Sarcopenia Muscle, 2018,9(1):106-118.

73.Li Y#, Qin R, Yan H, Wang F, Huang S, Zhang Y, Zhong M, Zhang W, Wang Z*, Inhibition of vascular smooth muscle cells premature senescence with rutin attenuates and stabilizes diabetic atherosclerosis, J Nutr Biochem, 2018,51:91-98.

74.Sui DX#, Zhou HM, Wang F, Zhong M, Zhang W, Ti Y*, Cell death-inducing DFF45-like effector C gene silencing alleviates pulmonary vascular remodeling in a type 2 diabetic rat model, J Diabetes Investig, 2018,9(4):741-752.

75.Wang F#, Han L, Qin RR, Zhang YY, Wang D, Wang ZH, Tang MX, Zhang Y, Zhong M, Zhang W*, Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE-/- /LDLR-/- mouse via a PPARγ/CD36 pathway, J Cell Mol Med, 2017, 21(12):3298-3308.

76.Sun X#, Song M, Wang H, Zhou H, Wang F, Li Y, Zhang Y, Zhang W, Zhong M, Ti Y*, TRB3 gene silencing activates AMPK in adipose tissue with beneficial metabolic effects in obese and diabetic rats.Biochem Biophys Res Commun, 2017, 488(1):22-28.

77.Wang H#, Ti Y, Zhang JB, Peng J, Zhou HM, Zhong M, Xing YQ, Zhang Y, Zhang W, Wang ZH*, Single nucleotide polymorphisms in CIDEC gene are associated with metabolic syndrome components risks and antihypertensive drug efficacy, Oncotarget, 2017, 8(16):27481-27488.

78.Li Y#, Yan H, Wang F, Huang S, Zhang Y, Wang Z, Zhong M, Zhang W*, Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice, Biochem Biophys Res Commun, 2017, 486(3):693-699.

79.Qin RR#, Song M, Li YH, Wang F, Zhou HM, Liu MH, Zhong M, Zhang Y, Zhang W, Wang ZH*, Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid Atherosclerosis in Metabolic Syndrome, Ann Clin Lab Sci, 2017, 47(1):47-51.

80.Fan GQ#, Qin RR, Li YH, Song DJ, Chen TS, Zhang W, Zhong M, Zhang Y, Xing YQ, Wang ZH*, Endothelial cells microparticle-associated protein disulfide isomerase promotes platelet activation in metabolic syndrome, Oncotarget, 2016, 7(50):83231-83240.

81.Ti Y#, Xie GL, Wang ZH, Ding WY, Zhang Y, Zhong M, Zhang W*, Tribbles 3: A potential player in diabetic aortic remodelling, Diab Vasc Dis Res, 2016, 13(1):69-80.

82.Fang NN#, Sui DX, Yu JG, Gong HP, Zhong M, Zhang Y, Zhang W*, Strain/strain rate imaging of impaired left atrial function in patients with metabolic syndrome. Hypertens Res, 2015, 38(11):758-764.

83.Fan GQ#, Fu KL, Song M, Han L, Jin CW, Zhong M, Zhang Y, Zhang W, Wang ZH*. The impact of metabolic syndrome and hypertension on medical costs of patients with acute myocardial infarction at hospital, Clin Exp Hypertens, 2015, 37(8):627-632.

84.Guo L#, Guo ZX, Gong HP, Shang YY, Zhong M, Zhang Y, Zhang W*, Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells, Mol Med Rep, 2015,12(2):1963-1970.

85.Fan GQ#, Fu KL, Jin CW, Wang XZ, Han L, Wang H, Zhong M, Zhang Y, Zhang W, Wang ZH*, A medical costs study of older patients with acute myocardial infarction and metabolic syndrome inhospital, Clin Interv Aging, 2015, 10:329-337.

86.Li WB#, Zhao J, Liu L, Wang ZH, Han L, Zhong M, Zhang Y, Zhang W, Tang MX*, Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats, Acta Diabetol, 2015, 52(4):717-726.

87.Peng J#, Zhao Y, Zhang H, Liu Z, Wang Z, Tang M, Zhong M, Lu F, Zhang W*, Prevention of metabolic disorders with telmisartan and indapamide in a Chinese population with high-normal blood pressure, Hypertens Res, 2015, 38(2):123-131.

88.Peng J#, Lu F, Wang Z, Zhong M, Sun L, Hu N, Liu Z, Zhang W*, Excessive lowering of blood pressure is not beneficial for progression of brain white matter hyperintensive and cognitive impairment in elderly hypertensive patients: 4-year follow-up study, J Am Med Dir Assoc, 2014, 15(12):904-910.

89.Fu KL#, Fan GQ, Han L, Wang XZ, Wang J, Wang YS, Zhong M, Zhang Y, Zhang W, Wang ZH*, Impact of type 2 diabetes mellitus on hospitalization costs in older patients with acute myocardial infarction, Clin Interv Aging, 2014, 9:711-718.

90.Li Y#, Ding W, Wang H, Song N, Lin L, Wang Z, Zhong M, Zhang Y, Zhang W*, Relationship of CHA2DS2-VASc and CHADS2 score to left atrial remodeling detected by velocity vector imaging in patients with atrial fibrillation, PLoS One, 2013, 8(10):e77653.

91.Zhang W#, Tang M, Zhong M, Wang Z, Shang Y, Gong H, Zhang Y, Zhang W*, Association of the six transmembrane protein of prostate 2 gene polymorphisms with metabolic syndrome in Han Chinese population, Diabetes Metab Syndr, 2013, 7(3):138-142.

92.Liu L#, Ding WY, Zhao J, Wang ZH, Zhong M, Zhang W, Chen YG, Zhang Y, Li L, Tang MX*, Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3, Int J Biochem Cell Biol, 2013, 45(9):2027-2035.

93.Wang ZH#, Shang YY, Zhang S, Zhong M, Wang XP, Deng JT, Pan J, Zhang Y, Zhang W*, Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice, Diabetes, 2012, 61(2):463-473.

94.Wang H#, Wang ZH, Kong J, Yang MY, Jiang GH, Wang XP, Zhong M, Zhang Y, Deng JT, Zhang W*, Oxidized low-density lipoprotein-dependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress, Mol Med, 2012, 18:159-166.

95.Wang ZH#, Gong HP, Shang YY, Tang MX, Fang NN, Jiang GH, Zhang Y, Zhong M, Zhang W*, An integrative view on the carotid artery alterations in metabolic syndrome, Eur J Clin Invest, 2012,42(5):496-502.

96.Zhu H#, Zhang W, Zhong M, Zhang G, Zhang Y*, Differential gene expression during atrial structural remodeling in human left and right atrial appendages in atrial fibrillation, Acta Biochim Biophys Sin (Shanghai), 2011, 43(7):535-541.

97.Wang H#, Yan HM, Tang MX, Wang ZH, Zhong M, Zhang Y, Deng JT, Zhang W*, Increased serum levels of microvesicles in nonvalvular atrial fibrillation determinated by ELISA using a specific monoclonal antibody AD-1, Clin Chim Acta, 2010,411(21-22):1700-1704.

98.Zhu H#, Zhang W, Zhong M, Zhang G, Zhang Y*, Myocardial ultrasonic integrated backscatter analysis in patients with chronic atrial fibrillation, Int J Cardiovasc Imaging, 2010, 26(8):861-865.

99.Meng X#, Qie L, Wang Y, Zhong M, Li L*, Assessment of arterial stiffness affected by atorvastatin in coronary artery disease using pulse wave velocity, Clin Invest Med, 2009, 32(6):E238.

100.Wang ZH#, Liu XL, Zhong M, Zhang LP, Shang YY, Hu XY, Li L, Zhang Y, Deng JT, Zhang W*, Pleiotropic effects of atorvastatin on monocytes in atherosclerotic patients, J Clin Pharmacol, 2010, 50(3):311-319.

101.Li SH#, Yang B, Gong HP, Tan HW, Zhong M, Zhang Y, Zhang W*, Impaired atrial synchronicity in patients with metabolic syndrome associated with insulin resistance and independent of hypertension, Hypertens Res, 2009, 32(9):791-796.

102.Li SH#, Yang B, Gong HP, Tan HW, Zhong M, Zhang Y, Zhang W*, Impaired left ventricular synchronicity in patients with metabolic syndrome regardless of hypertension, J Hypertens, 2009, 27(4):869-75.

103.Shang YY#, Zhong M, Zhang LP, Guo ZX, Wang ZH, Zhang Y, Deng JT, Zhang W*, Tribble 3, a novel oxidized low-density lipoprotein-inducible gene, is induced via the activating transcription factor 4-C/EBP homologous protein pathway, Clin Exp Pharmacol Physiol, 2010, 37(1):51-55.

104.Sun H#, Zhong M, Miao Y, Ma X, Gong HP, Tan HW, Zhang Y, Zhang W*, Impaired elastic properties of the aorta in fat-fed, streptozotocin-treated rats, Vascular remodeling in diabetic arteries, Cardiology, 2009, 114(2):107-113.

105.Shang YY#, Wang ZH, Zhang LP, Zhong M, Zhang Y, Deng JT, Zhang W*, TRB3, upregulated by ox-LDL, mediates human monocyte-derived macrophage apoptosis, FEBS J, 2009, 276(10):2752-2761.

106.Gong HP#, Tan HW, Fang NN, Song T, Li SH, Zhong M, Zhang W, Zhang Y*, Impaired left ventricular systolic and diastolic function in patients with metabolic syndrome as assessed by strain and strain rate imaging, Diabetes Res Clin Pract, 2009, 83(3):300-307.

107.Qie L#, Meng X, Wang Y, Feng M, Zhong M, Li L*, Assessment of regional systolic and diastolic functions affected by atorvastatin in coronary artery disease using tissue Doppler imaging, Clin Cardiol, 2008, 31(11):551-555.

108.Zhang W#, Zhong M, Yang GR, Li JP, Guo C, Wang Z, Zhang Y*, Matrix metalloproteinase-9/tissue inhibitors of metalloproteinase-1 expression and atrial structural remodeling in a dog model of atrial fibrillation: inhibition with angiotensin-converting enzyme, Cardiovasc Pathol, 2008, 17(6):399-409.

109.Zhang W#, Ma X, Zhong M, Zheng Z, Li L, Wang Z, Zhang Y*, Role of the calpain system in pulmonary vein connexin remodeling in dogs with atrial fibrillation,Cardiology, 2009, 112(1):22-30.

110.Xing SS#, Tan HW, Bi XP, Zhong M, Zhang Y, Zhang W*, Felodipine reduces cardiac expression of IL-18 and perivascular fibrosis in fructose-fed rats, Mol Med, 2008, 14(7-8):395-402.

111.Wang Z#, Tan H, Zhong M, Jiang G, Zhang Y, Zhang W*, Strain rate imaging for noninvasive functional quantification of the left atrium in hypertensive patients with paroxysmal atrial fibrillation, Cardiology, 2008, 109(1):15-24.

112.Zhong JQ#, Zhang W, Gao H, Li Y, Zhong M, Li D, Zhang C, Zhang Y*, Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs, Eur J Heart Fail, 2007, 9(1):23-29.

获得学术奖励(仅不列此项时可删除该标题,标题序号按实际情况编排)

(1) 钟明(2/10),代谢综合征及相关疾病防治的转化医学,山东省人民政府,山东省科技进步奖,一等奖,2012

(张薇,钟明,张运,王志浩,唐梦熊,巩会平,尚嫄嫄,毕秀萍,李少华,谭红伟)

(2) 钟明(3/11),持续性心房颤动心房重构机制和栓塞并发症防治的研究,山东省人民政府,山东省科技进步奖,一等奖,2007

(张薇,张运,钟明,朱慧,杨贵荣,李建平,皮延生,马骁,张学义,张供,马长生)

(3) 钟明(2/10),冠状循环检测方法和临床意义的研究,教育部,教育部科技进步奖,二等奖,2004

(张薇,钟明,张运,郑兆通,赵静,安丰双,白晨,张学义,葛志明,季晓平)

(4) 钟明(1/9),舒张性心力衰竭发病机制、诊断和治疗的研究,山东省人民政府,山东省科技进步奖,二等奖,2003

(钟明,张运,张薇,卜培莉,钟敬泉,赵静,安丰双,季晓平,张梅)

(5) 钟明(2/9),冠状循环血流动力学的临床研究,山东省人民政府,山东省科技进步奖,二等奖,2002

(张薇,钟明,张运,安丰双,白晨,张学义,葛志明,季晓平,赵静)

(6) 钟明(5/5),多平面经食管超声心动图的临床研究,国务院,国家科技进步奖,三等奖,1997

(张运,张薇,张梅,姚桂华,钟明)