卜培莉-山东大学心血管重构与功能研究重点实验室

主要研究方向：高血压、心血管重构的基础和临床研究。曾获评山东省十佳女医师、山东大学优秀临床教授，获得山东大学优秀硕士研究生论文指导奖。作为项目负责人或骨干承担或参加国家自然基金、973前期课题子课题、国家重点研发项目子课题、山东省自然基金、山东省科技发展计划等项目10余项，发表SCI文章27篇，获得高等学校科技进步二等奖及其他奖项共6项。为国家自然科学基金及山东省科技攻关课题等评审专家，并任《中华心力衰竭和心肌病杂志》、《山东大学学报（医学版）》、《Clinical Cardiology》等数个专业期刊的编委或审稿专家，主编或参编著作7部。

时间	名称	期刊	位次（*代表通讯）
2009	Effects and mechanisms of PPARalpha activator fenofibrate on myocardial remodelling in hypertension	J Cell Mol Med	12*/12
2010	PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity	Biochem Biophys Res Commun	6*/7
2011	Rosiglitazone attenuates myocardial remodeling in spontaneously hypertensive rats	Hypertens Res	10*/10
2011	Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome	Diabetes Res Clin Pract	3*/3
2012	Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension	BMC Cardiovasc Disord	8*/8
2012	Antagonist of microRNA-21 improves balloon injury-induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts	J Cell Biochem	11*/11
2012	Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension	J Hum Hypertens	7*/7
2013	Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress.	Int J Mol Sci	5*/7
2013	PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1.	Eur J Pharmacol	7*/7
2013	Associations of CXCL16/CXCR6 with carotid atherosclerosis in patients with metabolic syndrome.	Clin Nutr.	4*/4
2014	.Pathways involved in interleukin-1β-mediated murine cardiomyocyte apoptosis.	Tex Heart Inst J	3*/3
2014	Amiodarone-induced epididymitis: a pathologically confirmed case report and review of the literature.	Cardiology	4*/4
2014	Levels of acylation stimulating protein and the complement component 3 precursor are associated with the occurrence and development of coronary heart disease.	Exp Ther Med	9*/10
2015	In vitro, ex vivo and in vivo anti-hypertensive activity of Chrysophyllum cainito L. extract.	Int J Clin Exp Med.	6*/6
2015	Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway.	Am J Physiol Heart Circ Physiol.	9*/9
2015	Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD.	PLoS One.	8*/8
2015	Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia.	Neuropeptides.	7*/7
2015	Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.	Cell Death Dis	10*/10
2015	Role of SIRT3 in Angiotensin II-induced human umbilical vein endothelial cells dysfunction.	BMC Cardiovasc Disord	5*/5
2016	Progress on the cardiotoxicity of sunitinib: Prognostic significance, mechanism and protective therapies.	chemico-biological interactions	2*/2
2016	.Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1.	Oncotarget	12*/12
2016	Melatonin attenuates angiotensin II-induced cardiomyocyte hypertrophy through the CyPA/CD147 signaling pathway.	Mol Cell Biochem	9*/9
2017	SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension.	Oncotarget.	12*/12
2017	SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway	Am J Transl Res	5*/5
2017	SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through β-catenin/PPAR-γ signaling.	Life Sci	8*/8
2017	Correlations of Serum Cyclophilin A and Melatonin Concentrations with Hypertension-induced Left Ventricular Hypertrophy	ARCH MED RES /archives of medical research	7*/7
2018	Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury	JOURNAL OF TRANSLATIONAL MEDICINE	6*/6
2019	The Expression and Clinical Significance of Spleen Tyrosine Kinase in Patients with Coronary Heart Disease.	Medical science monitor : international medical journal of experimental and clinical research	6*/6
2019	Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro	Archives of toxicology	10*/10
2019	Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway.	Pharmaceutical biology	7*/7
2008	Tong-xin-luo capsule inhibits left ventricular remodeling in spontaneously hypertensive rats by enhancing PPAR-gamma expression and suppressing NF-kappaB activity	Chinese Medical Journal	6/6.

1.2012.01-2015.12 《外膜成纤维细胞microRNA-21在血管重塑中的作用的研究（编号81170135）》负责人国家自然科学基金面上项目

2.2011.01-2013.12《Sirt3和PPARα对心肌代谢重构的影响及机制的研究（编号81070076）》负责人国家自然科学基金面上项目

3.2012.01-2014.12《重大疾病致病机理及防治的基础问题研究：代谢性因素在心力衰竭发病中的作用机制研究（编号2012CB722406）》课题负责人 973前期课题子课题

4.2005.01《心肌细胞及外基质重构及心肌脂肪代谢中PPARs的调控机制和药物预研究》省级山东省自然科学基金

5.2007.01《PPARs在自发性高血压大鼠肾纤维化中的调控机制》省级山东省科技发展计划项目

6.2010.01《代谢相关miRNA在心肌肥厚中的作用及机制》山东大学自主创新基金自然科学

7.2009.12-2012.12《血管外膜成纤维细胞MicroRNA在血管重塑制中的作用的研究（编号ZR2009CM026）》课题承担人山东省自然科学基金

8.2016.01-2020.12 《ADAM17对糖尿病心肌纤维化的影响及其分子机制研究（编号81530014）》骨干国家自然基金重点项目

9.2017.07-2020.12 《心衰患者分级诊疗、救治及转诊模式的建立和评价（骨干）(编号2017YFC1308303）》骨干国家重点研发项目

10.2017.1-2017.12 《Sirt3去乙酰化修饰的KLF11在心肌成纤维细胞转分化中的作用及机制研究（编号81641013）》负责人国家自然科学基金应急课题

11.2017.3-2018.12《Sirt3对高血压心肌重构中微血管新生的影响及分子机制研究（编号2017GSF18137）》项目负责人山东省重点研发计划

12.2018.1-2021.12 《脉络学说代表方稳定易损斑块临床疗效及机制研究（编号2017YFC1700502）》课题负责人国家重点研发项目

中华医学会心血管病学分会全国委员及女性健康学组副组长

中国医师协会高血压分会全国委员及相关代谢工作组副组长

中国医师协会心脏重症分会全国委员

山东省医学会心血管分会副主任委员及高血压学组组长

山东省医师协会心血管医师分会副主任委员

山东省医学会心脏康复分会副主任委员

山东省中西医结合学会心血管分会副主任委员

高血压中医临床诊疗实践指南专题委员会委员

中国医疗保健国际交流促进会高血压分会常务委员

中国高血压联盟理事

山东省健康管理协会高血压健康管理分会副主任委员

国家心血管病中心高血压专病医联体副理事长

国家心血管病中心高血压专病医联体山东省中心主任

中国医师协会高血压分会质控管理工作委员会委员

中国女医师协会心脏康复研究中心常务委员

中国中药协会微循环用药专业委员会副主任委员

中国心脏联盟心血管疾病预防与康复学会第一届常务委员

山东省心衰中心联盟专家委员会副主任委员等

卜培莉

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