山东大学齐鲁医院心内科副主任医师；山东大学副教授，博士生导师。首批山东省齐鲁卫生与健康杰出青年人才，首届山东大学齐鲁医学院名医（杰出青年医师），山东大学齐鲁医院杰出青年人才。主要从事冠心病、高血压、心力衰竭等心血管疾病的诊治，尤其擅长心血管疾病介入治疗。2017和2018年度中国医师协会冠脉介入委员会优秀青年医师。近年来以项目负责人承担国家自然科学基金3项，山东省课题2项；作为课题骨干承担包括国家重点研发计划，国家自然科学基金重大国际合作项目、重点项目、重大研究计划、面上项目等20余项。发表SCI杂志论文50篇，中文核心期刊10余篇，其中以第一或通讯作者发表SCI论文20篇。获省部级奖励5项。

1.Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J(Co-Corresponding author), Bu P. Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3. Oxid Med Cell Longev. 2021;2021: 6668887.

2.Fang Y, Yang J(co-first author), Zu G, Cong C, Liu S, Xue F, Ma S, Liu J, Sun Y, Sun M. Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression and Metastasis via p38 Signaling Pathway in Gastric Cancer. Front Oncol. 2021;11:565676.

3. Wu Z, Zhang W, Yang J. Letter by Wu et al Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis". Circulation. 2021 May 11;143(19):e919-e920.

4. Xue F, Yang J(co-first author), Cheng J, Sui W, Cheng C, Li H, Zhang M, Zhang J, Xu X, Ma J, Lu L, Xu J, Zhang M, Zhang Y, Zhang C*. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. Br J Pharmacol. 2020;177:1719-1734.

5. Sun Y, Guan J, Hou Y, Xue F, Huang W, Zhang W, Zhang Y, Zhang C, Yang J*(Corresponding author). Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE-/- mice. Clin Sci (Lond). 2019. 133(11): 1215-1228.

6. Zhang Q, Liu X, Li N, Zhang J, Yang J(Co-Corresponding author), Bu P. Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury. J Transl Med. 2018. 16(1): 313.

7. Li W, Li J, Hao P, Chen W, Meng X, Li H, Zhang Y, Zhang C, Yang J*(Corresponding author). Imbalance between angiotensin II and angiotensin-(1-7) in human coronary atherosclerosis. J Renin Angiotensin Aldosterone Syst. 2016. 17(3).

8. Yang J, Sun Y, Dong M, Yang X, Meng X, Niu R, Guan J, Zhang Y*, Zhang C*. Comparison of angiotensin-(1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice. Atherosclerosis. 2015;240:544-549.

9. Yang J, Yang X, Meng X, Dong M, Guo T, Kong J, Zhang K, Zhang Y*, Zhang C*. Endogenous activated angiotensin-(1-7) plays a protective effect against atherosclerotic plaques unstability in high fat diet fed ApoE knockout mice. Int J Cardiol. 2015;184:645-652.

10. Hao P, Yang J(Co-first author), Liu Y, Zhang M, Zhang K, Gao F, Chen Y, Zhang C*, Zhang Y*. Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy. Sci Rep. 2015;5:8794.

11. Meng X, Yang J(Co-first author), Zhang K, An G, Kong J, Jiang F, Zhang Y*, Zhang C*. Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice. Hypertension. 2014;64:875-882.

12. Yang JM, Dong M, Meng X, Zhao YX, Yang XY, Liu XL, Hao PP, Li JJ, Wang XP, Zhang K, Gao F, Zhao XQ, Zhang MX, Zhang Y*, Zhang C*. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol. 2013;33:1978-1985.

13. Yang J, Zhao Y, Hao P, Meng X, Dong M, Wang Y, Zhang Y*, Zhang C*. Impact of angiotensin I converting enzyme insertion/deletion polymorphisms on dilated cardiomyopathy and hypertrophic cardiomyopathy risk. PLoS One. 2013;8:e63309.

14. Meng X, Li W, Yang J(Co-first author), Zhang K, Qin W, An G, Gao F, Wang Y, Zhang C*, Zhang Y*. Regulatory T cells prevent plaque disruption in apolipoprotein E-knockout mice. Int J Cardiol. 2013;168:2684-2692.

15. Yang J, Liu Z, Zhang C, Zhao Y, Sun S, Wang S, Zhao Y, Zhang Y, Li J*, Lu F*. The prevalence of hyperuricemia and its correlates in an inland Chinese adult population, urban and rural of Jinan. Rheumatol Int. 2013;33:1511-1517.

16. Zhang H#, Sun M#, Sun T, Zhang C, Meng X, Zhang Y, Yang J*(Corresponding author). Association between Angiotensin II Type 1 Receptor Gene Polymorphisms and Ischemic Stroke: A Meta-Analysis. Cerebrovasc Dis. 2011;32:431-438.

17. Zhang H#, Sun ML#, Peng J#, Sun T, Zhang Y, Yang JM*(Corresponding author). Association of the angiotensin type 1 receptor gene A1166C polymorphisms with myocardial infarction: a meta-analysis. J Thromb Haemost. 2011;9:1258-1260.

18. Yang JM, Wang Y, Qi LH, Wang Y, Gao F, Ding SF, Ni M, Liu CX, Zhang C*, Zhang Y*. Combinatorial interference of toll-like receptor 2 and 4 synergistically stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice. J Cell Mol Med. 2011;15:602-611.

19. Yang J, Lu F, Zhang C, Liu Z, Zhao Y, Gao F, Sun S, Zhao Y, Zhang Y*. Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007. Hypertens Res. 2010;33:331-337.

20. Gong S, Gao X, Xu F, Shang Z, Li S, Chen W, Yang J*(Corresponding author), Li J. Association of lymphocyte to monocyte ratio with severity of coronary artery disease. Medicine. 2018;97(43):e12813.

21. Li S, Zhang X, Dong M, Gong S, Shang Z, Jia X, Chen W, Yang J*(Corresponding author), Li J. Effects of spironolactone in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials. Medicine. 2018;97(35):e11942.

22. Meng X, Yang J, Dong M, Zhang K, Tu E, Gao Q, Chen W, Zhang C*, Zhang Y. Regulatory T cells in cardiovascular diseases. Nat Rev Cardiol. 2016;13(3):167-79.

23. Hao PP, Yang JM, Zhang MX, Zhang K, Chen Y, Zhang C, Zhang Y*. Angiotensin-(1-7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2015;308(9):H1007-19.

24. Zhang K, Meng X, Li D, Yang J, Kong J, Hao P, Guo T, Zhang M, Zhang Y*, Zhang C*. Angiotensin(1-7) attenuates the progression of streptozotocin-induced diabetic renal injury better than angiotensin receptor blockade. Kidney Int. 2015;87(2):359-369.

25. Hao PP, Jiang F, Chen YG, Yang J, Zhang K, Zhang MX, Zhang C, Zhao YX*, Zhang Y. Traditional Chinese medication for cardiovascular disease. Nat Rev Cardiol. 2015;12(2):115-122.

26. Liu X, Ni M, Ma L, Yang J, Wang L, Liu F, Dong M, Yang X, Zhang M, Lu H, Wang J, Zhang C, Jiang F*, Zhang Y*. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization. Sci Rep. 2015;5:10225.

27. Liu Y, Li B, Wang X, Li G, Shang R, Yang J, Wang J, Zhang M, Chen Y, Zhang Y, Zhang C*, Hao P*. Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor. Mol Med. 2015;21:626-636.

28. Jiang F, Yang J, Zhang Y, Dong M, Wang S, Zhang Q, Liu FF, Zhang K, Zhang C*. Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets. Nat Rev Cardiol. 2014;11(7):413-26.

29. Meng X, Kong J, Zhang K, Yang J, Li J*, Zhang Y*. Association of resistin-like molecule beta levels and abdominal aortic aneurysm. Int J Cardiol. 2014. 181C: 8-10.

30. Zhang X, Li Q, Zhao J, Li X, Sun X, Yang H, Wu Z*, Yang J. Effects of combination of statin and calcium channel blocker in patients with cardiac syndrome X. Coron Artery Dis. 2014;25:40-44.

31. Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Lanne T, Sun B, Li X, Liu Y, Zhang Y*, Cao Y*. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab. 2013;18:118-129.

32. Zhang K, Meng X, Kong J, Liu FF, Yang JM, Gao F, Zhang Y, Zhang C*. Simvastatin increases Prolyl-4-Hydroxylase alpha1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling. J Mol Cell Cardiol. 2013;65:43-50.

33. Guo T, Wang J, Yang J, Chen W, An G, Fan L, Peng Q*. Lentivirus-mediated RNA interference of chymase increases the plaque stability in atherosclerosis in vivo. Exp Mol Pathol. 2013;95:51-56. (IF:2.706)

34. Hao PP, Chen YG, Liu YP, Zhang MX, Yang JM, Gao F, Zhang Y*, Zhang C*. Association of plasma angiotensin-(1-7) level and left ventricular function in patients with type 2 diabetes mellitus. PLoS One. 2013;8:e62788.

35. Meng X, Zhang K, Li J, Dong M, Yang J, An G, Qin W, Gao F, Zhang C*, Zhang Y*. Statins induce the accumulation of regulatory T cells in atherosclerotic plaque. Mol Med. 2012;18:598-605.

36. Li JJ, Meng X, Si HP, Zhang C, Lv HX, Zhao YX, Yang JM, Dong M, Zhang K, Liu SX, Zhao XQ, Gao F, Liu XL, Cui TX*, Zhang Y*. Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arterioscler Thromb Vasc Biol. 2012;32:1158-1166.

37. Hao PP, Zhang MX, Li RJ, Yang JM, Wang JL, Chen YG*, Zhang Y. Clopidogrel 150 vs. 75 mg day(-1) in patients undergoing percutaneous coronary intervention: a meta-analysis. J Thromb Haemost. 2011;9:627-637.

38. Zhao XQ, Zhang MW, Wang F, Zhao YX, Li JJ, Wang XP, Bu PL, Yang JM, Liu XL, Zhang MX, Gao F, Zhang C*, Zhang Y*. CRP enhances soluble LOX-1 release from macrophages by activating TNF-alpha converting enzyme. J Lipid Res. 2011;52:923-933.

39. Wang Y, Zhang MX, Meng X, Liu FQ, Yu GS, Zhang C, Sun T, Wang XP, Li L, Wang YY, Ding SF, Yang JM, Zhang Y*. Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells. Am J Physiol Heart Circ Physiol. 2011;300:H1743-1752.

40. Li WJ, Yu H, Yang JM, Gao J, Jiang H, Feng M, Zhao YX*, Chen ZY*. Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain Res. 2010;1347:71-79.

41. Liu P, Zhang C, Feng JB, Zhao YX, Wang XP, Yang JM, Zhang MX, Wang XL, Zhang Y*. Cross talk among Smad, MAPK, and integrin signaling pathways enhances adventitial fibroblast functions activated by transforming growth factor-beta1 and inhibited by Gax. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):725-31.

42. Yang X, Sui W, Zhang M, Dong M, Lim S, Seki T, Guo Z, Fischer C, Lu H, Zhang C, Yang J, Zhang M, Wang Y, Cao C, Gao Y, Zhao X, Sun M, Sun Y, Zhuang R, Samani NJ, Zhang Y, Cao Y. Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. JCI Insight. 2017;2(4):e89044.

43. Li H, Li J, Jiang X, Liu S, Liu Y, Chen W, Yang J, Zhang C, Zhang W*. Melatonin enhances atherosclerotic plaque stability by inducing prolyl-4-hydroxylaseα1 expression. J Hypertens. 2019;37:964-971.

44. Li J, Gong L, Liu S, Zhang Y, Zhang C, Tian M, Lu H, Bu P, Yang J, Ouyang C, Jiang X, Wu J, Zhang Y, Min Q, Zhang C*, Zhang W*. Adipose HuR protects against diet-induced obesity and insulin resistance. Nat Commun. 2019;10:2375.

45. Qin X, He L, Tian M, Hu P, Yang J, Lu H, Chen W, Jiang X, Zhang C, Gao J, Chen M, Weinstein LS, Zhang Y*, Zhang W*. Smooth muscle-specific Gsαdeletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. J Mol Cell Cardiol. 2019;132:49-59.

46. Li H, Qin X, Yang J, Ouyang C, Wu J, Jiang X, Gao J, Min Q, Zhang C*, Zhang W*. Smooth muscle-specific LKB1 deletion exaggerates angiotensin II-induced abdominal aortic aneurysm in mice. J Mol Cell Cardiol. 2019;130:131-139.

47. Liu S, Jiang X, Cui X, Wang J, Liu S, Li H, Yang J, Zhang C, Zhang W. Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.Cell Death Dis. 2021;12(4):385.

48. Tian M, Wang J, Liu S, Li X, Li J, Yang J, Zhang C, Zhang W. Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN.Cell Death Dis. 2021 Mar 4;12(3):236.

49. Tian M, Jiang X, Li X, Yang J, Zhang C, Zhang W. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. J Cell Mol Med. 2021 Mar;25(5):2517-2529.

50. Zhang T, Li H, Ouyang C, Cao G, Gao J, Wu J, Yang J, Yu N, Min Q, Zhang C, Zhang W. Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. Redox Biol. 2021;38:101828.

（一）主持项目：

（1）国家自然科学基金面上项目“Collectrin调控动脉粥样硬化的作用及机制研究”（项目资助号：81970366；项目起止年月2020-01至2023-12）。

（2）国家自然科学基金面上项目“ACE2-Ang-(1-7)轴在心肌缺血再灌注损伤中的作用及其机制研究”（项目资助号：81570324；项目起止年月2016-01至2019-12）。

（3）国家自然科学基金青年科学基金“JAML在动脉粥样硬化发生发展中作用机制的研究”（项目资助号：81100207；项目起止年月2012-01至2014-12）。

（4）山东省重点研发项目“ACE2-Ang-(1-7)轴预测冠心病患者冠状动脉斑块易损性的临床研究” （项目资助号：2015GSF118118；项目起止年月2015-1至2016-12）。

（5）山东省优秀中青年科学家奖励基金“新型连接粘附分子JAML调控动脉粥样硬化过程中巨噬细胞功能的机制研究”（项目资助号：BS2013SW009；项目起止年月2013-10至2015-10）。

（二）参与项目：

（1）国家自然科学基金重大国际合作研究“促红细胞生成素导致腹主动脉瘤形成的作用及分子机制研究”（项目资助号：81920108003；项目起止年月：2020-01至2023-12）。国内第3位。

（2）国家自然科学基金重点项目“ADAM17对糖尿病心肌纤维化的影响及其分子机制研究” 项目资助号：81530014；项目起止年月：2016-01至2020-12）。经费：第5位。

（3）国家自然科学基金面上项目“HuR在尼古丁促进内皮功能损伤及动脉粥样硬化斑块形成和破裂中的作用及机制研究”（项目资助号：81570393；项目起止年月：2016-01至2019-12）。第2位。

（4）国家自然科学基金重大研究计划培育项目“AMPK羰基化修饰在动脉粥样硬化斑块进展中的作用及其分子机制研究”（项目资助号：91339109；项目起止年月：2014-01至2017-12）。第2位。

（5）国家自然科学基金重大国际合作研究“糖尿病促进动脉粥样硬化斑块易损的分子机制研究” 项目资助号：81320108004；项目起止年月：2014-01至2018-12）。国内第5位。

（6）国家自然科学基金面上项目“AMPK在糖尿病抑制腹主动脉瘤形成中的作用及转化医学研究”（项目资助号：81470591；项目起止年月：2015-01至2018-12）。第3位。

（7）国家自然科学基金面上项目“转录因子AP-2a在AMPK所介导的抗动脉粥样硬化中的作用及机制研究”（项目资助号：81370411；项目起止年月：2014-01至2017-12）。第2位。

（8）国家自然科学基金面上项目“AngII-ACE2-Ang-(1-7)在腹主动脉瘤发病和干预中的作用及其机制研究”（项目资助号：81270350；项目起止年月：2013-01至2016-12）。第2位。

美国心脏病学院Fellow（FACC）

山东省医学会心血管病学分会青年学组副组长

中国医药教育协会临床用药评价专业委员会委员

中国高血压联盟青年理事

中国医师协会中西医结合医师分会心血管病学专业委员会委员

山东省医学会心血管病学分会基础学组秘书

山东省卒中学会青年理事会常务理事

山东省医师协会高血压专业青年委员会委员

山东中西医结合学会介入心脏病专业委员会委员

山东省医药生物技术学会临床转化医学专业委员会委员