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博士生导师

陈文强

主任医师
博士研究生导师
个人简介 学术论文 科研项目 学会任职

1987年9月~1992年6月毕业于徐州医科大学临床医疗系获得学士学位,1999年9月~2001年6月获得山东大学硕士学位,2001年9月~2004年6月获得山东大学博士学位。国家卫健委冠心病介入培训导师。中华医学会冠心病介入学组委员,中国医师协会胸痛委员会常委,中国医疗保健国际交流促进会胸痛分会常务委员,山东省医师协会胸痛专业委员会副主任委员,山东省医学会心血管病学分会委员兼秘书长,山东省医学会心脏介入病学分会委员,山东省卒中学会心血管病分会副主任委员,山东省医师协会心血管介入分会委员,中国康复联盟山东省分会副主任委员。主持国家自然科学基金3项,国家重大项目1项,山东省自然科学基金1项,山东省卫生厅课题一项。作为第一作者或通信作者发表论文30余篇,其中SCI 21篇。获得2007年度国家科技进步二等奖1项。擅长冠心病的介入治疗。

1.Chen WQ, Zhang Y, Zhang M, Yin Y,Zhu YF. Establishing an animal model of unstable atherosclerotic plaques. Chin Med J(Engl), 2004;117(9):1293-1298.

2.Chen WQ, Zhang L, Liu YF, Chen L, Ji XP, Zhang M, Zhao YX, Yao GH, Zhang C, Wang XL, Zhang Y. Prediction of Atherosclerotic Plaque Ruptures with High Frequency Ultrasound Imaging and Serum Inflammatory Markers. Am J Physiol Heart Circ Physiol. 2007;293(5):H2836-844.

3.Chen WQ, Zhang M, Ji XP, Ding SF, Zhao YX, Chen YG, Zhang C, Zhang Y. Usefulness of high frequency vascular ultrasound imaging and serum inflammatory markers to predict plaque rupture in patients with stable and unstable angina pectoris. Am J Cardiology, 2007;100(9):1341-1346.

4.Chen WQ, Zhong L, Zhang L, Ji XP, Zhang M, Zhao YX, Zhang C, Zhang Y. Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels. Br J Pharmacol. 2009; 156:141-151.

5.Chen WQ, Zhong L, Zhang L, Ji XP, Zhao YX, Zhang C, Jiang H, Wu YL, Zhang Y. Chinese medicine tongxinluo significantly lowers serum lipid levels and stabilizes vulnerable plaques in a rabbit model. J Ethnopharmacology. 2009; 124: 103–110.

6.Chen WQ, Cai H, Zhang C, Ji XP, Zhang Y. Is overall blockade superior to selective blockade of adrenergic receptor subtypes in suppressing left ventricular remodeling. Hypertension Research. 2010: 33:1071-1081.

7.Li J, Guo Y, Luan X, Qi T, Li D, Chen Y, Ji X, Zhang Y, Chen WQ. Independent Roles of Monocyte Chemoattractant Protein-1, Regulated on Activation, Normal T-Cell Expressed and Secreted and Fractalkine in the Vulnerability of Coronary Atherosclerotic Plaques. Cir J. 2012;76(9): 2167-2173.

8.Zhao K, Xu XS, Meng X, Li YL, Li JF, Chen WQ. Autophagy of monocytes attenuates the vulnerability of coronary atherosclerotic plaques.Coron Artery Dis. 2013;24(8):651-6.

9.Zhai C, Cheng J, Mujahid H, Wang H, Kong J, Yin Y, Li J, Zhang Y, Ji X, Chen W. Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque. PLoS One. 2014; 9(3):e90563.

10.Li RJ, Yang M, Li JF, Xue L, Chen YG, Chen WQ. Circulating CD36 and fractalkine levels are associated with vulnerable plaque progression in patients with unstable angina pectoris. Clinical and Experimental Pharmacology and Physiology.2014; 41, 863–869.

11.Cheng J, Qiao L, Xu X, Zhai C, Zhao K, Ji X, Chen W. Lower AMP-activated protein kinase level is associated with the vulnerability of coronary atherosclerotic plaques by attenuating the expression of monocyte autophagy. Coron Artery Dis. 2015;26 (4):322-7.

12.Du J, Zhang D, Yin Y, Zhang X, Li J, Liu D, Pan F, Chen W. The Personality and Psychological Stress Predict Major Adverse Cardiovascular Events in Patients With Coronary Heart Disease After Percutaneous Coronary Intervention for Five Years. Medicine. 2016; 95(15):e3364.

13.Qiao L, Zhang X, Liu M, Liu X, Dong M, Cheng J, Zhang X, Zhai C, Song Y, Lu H, Chen W. Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells.Front Pharmacol. 2017;8:727.

14.Qiao L, Chen W. Atheroprotective effects and molecular targets of bioactive compounds from traditional Chinese medicine. Pharmacol Res. 2018 ;135:212-229.

15.Cheng J, Su X, Qiao L, Zhai C, Chen W.Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris. Biosci Rep. 2018;38(5).

16.Du J, Li Z, Jia G, Zhang Q, Chen W. Relationship between mental health and awareness of the knowledge on mental health in left-behind middle school students. Medicine (Baltimore). 2019;98(11):e14476.

17.Gao G,Jiang S, Ge L, Zhang S, Zhai C, Chen W, Sui S. Atorvastatin Improves Doxorubicin-Induced Cardiac Dysfunction by Modulating Hsp70, Akt, and MAPK Signaling Pathways.J Cardiovasc Pharmacol. 2019 ;73(4):223-231. (并列通讯作者)

18.Peng JQ, Han SM, Chen ZH, Yang J, Pei YQ, Bao C, Qiao L, Chen WQ, Liu B.Chaperone-mediated autophagy regulates apoptosis and the proliferation of colon carcinoma cells. Biochem Biophys Res Commun. 2019. pii: S0006-291X(19)32207-7. (并列通讯作者)

19.Li TT, Chen WQ, An FS, Tian HB, Zhang JN, Zhang Y, Guo YY. Probucol attenuates inflammation and increases stability of vulnerable atherosclerotic plaques in rabbits. Tohocu J Exp. Med. 2011; 225:23-34. (并列第一作者)

20.Zhong L, Chen WQ, Ji XP, Zhang M, Zhao YX, Yao GH, Zhang PF, Zhang C, Zhang Y. Dominant-negative Mutation of Monocyte Chemoattractant Protein-1 Prevents Vulnerable Plaques from Rupture in Rabbits Independent of Serum Lipid Levels. J Cell Mol Med. 2008 ;12(6A):2362-71. (并列第一作者)

21.Guo T, Chen WQ, Zhang C, Zhao YX, Zhang Y. Chymase activity is closely Related with plaque vulnerability in a hamster model of atherosclerosis. Atherosclerosis, 2009; 207:59-67. (并列第一作者)

1.主持人:2018-2020年 国家自然科学基金面上项目 分子伴侣介导的自噬调控perilipin2蛋白降解稳定动脉粥样硬化易损斑块的分子机制研究 (项目编号No. 81770436),资助55万元。

2.主持人:2016-2020年 国家“慢性非传染性疾病防控研究 ” 重点专项 《冠状动脉粥样硬化易损斑块的早期预警和干预研究》 (项目编号No. 2016YFC1300403),资助149.8万元。

3.主持人:2009-2011年 国家自然科学基金面上项目《基因缺失突变抑制白细胞趋化稳定动脉粥样硬化易损斑块的研究》(项目编号No. 30871040),资助32万元。

4.主持人:2010-2012年 国家自然科学基金面上项目《抑制PI3K/Akt/mTOR/p70S6K信号通路促进巨噬细胞自体吞噬稳定易损斑块分子机制研究》(项目编号No. 30971216),资助31万元。

5.主持人:2009-2011年 山东省自然科学基金《MCP-1、RANTES及Fractalkine联合缺失突变稳定AS易损斑块的研究 》项目编号No. Y2008C17),资助5万元。

6.主持人:2008-2010年 山东省卫生厅项目《Toll样受体的RNA干扰稳定动脉粥样硬化易损斑块的研究 》,资助1.2万元。

中华医学会冠心病介入学组委员

中国医师协会胸痛委员会常委

中国医疗保健国际交流促进会胸痛分会常务委员

山东省医师协会胸痛专业委员会副主任委员

山东省医学会心血管病学分会委员兼秘书长

山东省医学会心脏介入病学分会委员

山东省卒中学会心血管病分会副主任委员

山东省医师协会心血管介入分会委员

中国康复联盟山东省分会副主任委员