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王双喜
作者:  来源:  上传:xxgcg  发布时间:2012-08-06 03:41:18  浏览次数:7683

王双喜,男,19758月出生,教授,博士生导师。20056月在中南大学湘雅医学院获医学博士学位,2006年在美国俄克拉荷马大学进行博士后研究,2012年受聘为山东大学齐鲁青年学者”特聘教授。系AHA会员,为Acta Pharm SinLife ScienceJ Cardiovasc PharmacolMolecular and Cellular Biochemistry等多个国际学术期刊的审稿人。目前承担了973项目和国家科学基金项目等多项课题。主要研究细胞信号转导障碍与心血管疾病的关系,代表性研究论文如下:

1.        Shuangxi Wang, Cheng Zhang, Miao Zhang, Bin Liang, Jiyeon Lee, Huaiping Zhu, Benoit Viollet, Lijun Xia, Yun Zhang, Ming-Hui Zou. Activation of AMP-activated Protein Kinase alpha2 by Nicotine Instigates Formation of Abdominal Aortic Aneurysms in Mice in vivo. Nat Med, 2012;18(6):902-910. *Comment in (Editorial): Koichi Sugamura and John F. Keaney Jr. Nicotine: linking smoking to abdominal aneurysms. Nat Med, 2012;18(6):856-858.

2.         Shuangxi Wang, Bin Liang, Benoit Viollet, Ming-Hui Zou. Inhibition of the AMP-Activated Protein Kinase-alpha2 Accentuates Agonist-Induced Vascular Smooth Muscle Contraction and High Blood Pressure in Mice. Hypertension. 2011;57:1010-7.

3.        Shuangxi Wang, Miao Zhang, Bin Liang, Jian Xu, Zhonglin Xie, Chao Liu, Benoit Viollet, Daoguang Yan, Ming-Hui Zou. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res. 2010; 106(6):1117-28.

4.        Shuangxi Wang, Xu Jian, Song Ping, Benoit Viollet, Zou Ming-Hui. In Vivo Activation of AMP-activated Protein Kinase Attenuates Diabetes-enhanced Degradation of GTP Cyclohydrolase I. Diabetes, 2009; 58(8):1893-901.

5.        Shuangxi Wang, Jian Xu, Ping Song, Yong Wu, Ming-Hui Zou. Acute Inhibition of GTP Cyclohydrolase I Uncouples Endothelial Nitric Oxide Synthase and Elevates Systolic Blood Pressure. Hypertension, 2008; 52(3):484-490.

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